Synthesis and properties of DNA oligonucleotides with a zwitterionic backbone structure.
نویسندگان
چکیده
The nucleosyl amino acid (NAA)-modification of oligonucleotides is introduced, which enables the preparation of oligonucleotides with zwitterionic backbone structures. It is demonstrated that partially zwitterionic NAA-modified DNA oligonucleotides are capable of duplex formation with native polyanionic counterstrands and show retained sensitivity towards base-pairing mismatches.
منابع مشابه
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ورودعنوان ژورنال:
- Chemical communications
دوره 50 89 شماره
صفحات -
تاریخ انتشار 2014